About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes, and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope’s commitment to Diversity, Equity, and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds, and experiences to our work -- and that our teams align with the people we serve to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds, and perspectives; this is reflected in our work and represented in our people.

Position Summary

Dr. Yanhong Shi’s lab is looking for a highly motivated and productive staff scientist for stem cell research projects within the Department of Stem Cell Biology and Regenerative Medicine (Shi laboratory) at Beckman Research Institute of City of Hope located in the county of Los Angeles, California.

The Shi laboratory has been well known for stem cell research, including stem cell-based disease modeling and cell therapy development. This laboratory is one of the pioneers in stablishing disease models and cell therapies using the human induced pluripotent stem cell (iPSC) platform and has published extensively in this area. Some of the papers published by the Shi laboratories include Shi et al. Nature Reviews Drug Discovery 16: 115-130, 2017; Li et al. Cell Stem Cell 23: 239-251, 2018; Feng et al. Advanced Science 7: 2002155, 2020; Cell Stem Cell 28: 331-342.e5, 2021; Chen et al. Advanced Science: 8: e2101462, 2021; Cui et al. Nature Cancer 2: 932-949, 2021. See Shi lab website:https://www.cityofhope.org/people/shi-yanhong.

The Shi laboratory has established protocols for differentiating human iPSCs into a variety of cell types, including brain cells, blood cells, and organoids, and has developed cellular models and cell therapeutic candidates for diseases including Alzheimer’s disease, Canavan disease, and glioblastoma. The Shi laboratory has well-established experimental platform and sufficient funding for candidates who are interested in doing first-class science.

The staff scientist will lead a project on human iPSC-based disease modeling and therapeutic development for neurological disorders such as Alzheimer’s disease. Expected to write progress reports and high-quality manuscripts for publication.

Basic education, experience and skills required for consideration:

• The Staff Scientist must possess, at a minimum, the U.S. equivalent Bachelor’s or Master’s degree in an appropriate discipline, and will often have a Ph.D. or other doctoral level degree.
• Experience in cell culture and basic molecular biology.
• Experience with human iPSC culture, CRISPR/Cas9-mediated gene editing, neural differentiation of human iPSCs is a plus.
• Strong molecular biology background is preferred.

Additional Information:

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.