Postdoctoral Fellow

University of Kansas Medical Center

Kansas City, KS

Job posting number: #7051954

Posted: July 11, 2018

Application Deadline: Open Until Filled

Job Description

A postdoctoral position is available immediately for a highly-motivated, enthusiastic individual in the NIH-funded Genome Maintenance and Structural Biology group of Dr. Bret D. Freudenthal at the University of Kansas Medical Center (KUMC), located in Kansas City, Kansas. Interested applicants should have experience in either structural biology, single-molecule studies, enzyme kinetics, fluorescence microscopy, and/or biochemistry. In addition, applicants should possess excellent written and verbal communication skills, and the ability to conduct research both independently and collaboratively. The candidate selected for the position will work as part of a diverse research group, encompassing undergraduate, graduate, and postdoctoral level scientists, employing multiple structural and biochemical approaches to develop and execute projects broadly focusing on determining how genome stability is maintained in response to DNA damage at the atomic, molecular, and cellular levels. The Laboratory of Genome Maintenance and Structural Biology is equipped with an X-ray crystallography facility that complements its adjacent molecular biology and protein biochemistry laboratories. The salary for this position is commensurate with experience as determined by NIH guidelines. Though the position is fully funded, the successful candidate will be mentored and encouraged to apply for additional financial support. For more information, please see our website at

The Freudenthal group is affiliated with both the Department of Biochemistry and Molecular Biology and the Department of Cancer Biology, and is a member of the NCI-designated University of Kansas Cancer Center (KUCC), placing the group alongside other research groups world-renowned for their contributions to biochemistry, cancer biology, and human health. This exceptional training environment offers a highly supportive and collaborative scientific experience with access to groups possessing expertise in many diverse areas. KUMC is located in an especially vibrant and attractive part of Kansas City, and is both central to other prominent research institutions and amenable to living a high quality, affordable lifestyle. Kansas City is often ranked among the best American cities to live in.

Qualifications: Applicants must possess a doctoral level degree in a relevant field.

To apply, please send your CV, description of research experience, and contact information for three references to or apply directly at, Position J0010705

Select Publications:
1. Amy M. Whitaker, Tony S. Flynn, Bret. D. Freudenthal. 2018. Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nature Communications 9:399.
2. Schaich M.A., Smith M.R., Cloud A.S., Holloran S.M., Freudenthal B.D. (2017) Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues. Chem Res Toxicol
3. Amy M. Whitaker, Mallory S. Smith, Matthew A. Schaich, Bret. D. Freudenthal. 2017. Capturing a mammalian DNA polymerase extending from an oxidized nucleotide. Nucleic Acids Res.
4. Fouquerel, E., Lormand, J., Bose, A., Lee, H.T., Kim, G.S., Li, J., Sobol, R.W., Freudenthal, B.D., Myong, S., Opresko, P.L. (2016) Oxidative guanine base damage regulates human telomerase activity. Nat Struct Mol Biol 12: 1092-1100.
5. Freudenthal, B.D., Beard, W.A., Cuneo, M.J., Dyrkheeva, N.S., and Wilson, S.H. (2015) Capturing Snapshots of APE1 Processing DNA Damage. Nat Struct and Mol Biol 12: 1092-1100.
6. Freudenthal, B.D., et al. (2015) Uncovering the Polymerase-induced Cytotoxicity of an
Oxidized Nucleotide. Nature 517:635-9.
7. Freudenthal, B.D., et al. (2013) Observing a DNA Polymerase in Action. Cell 154:157-68.

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