Postdoctroal Researcher in Immunology
Chapel Hill, NC
Job posting number: #7057601
Posted: June 6, 2019
Application Deadline: July 6, 2019
Job DescriptionVilen lab is looking for enthusiastic and motivated postdoctoral researcher candidates.
Our lab focuses on the mechanisms underlying immune dysfunction in autoimmune disease. We identified that in systemic lupus erythematosus (SLE), defects in lysosome acidification reduce degradation of IgG-immune complexes that enter myeloid cells by phagocytosis. This defect leads to multiple pathologies associated with murine SLE. Our recently funded NIH/DOD grants propose translational studies to assess whether lysosome dysfunction underlies human SLE, and studies to assess whether restoring lysosome function prevents onset or attenuates progression of disease in mice. Other goals seek to define the molecular and genetic events that drive lysosome dysfunction. Thus, projects are available to study murine or human aspects of lupus. Detailed research information is available on our websites: https://www.vilenlab.com/ and https://www.med.unc.edu/microimm/directory/barbara-vilen-phd/.
Successful candidates require a background in immunology and experiences in murine models or human translational research. A sound track-record of publishing, and strong internal motivation are essential. Experiences in flow cytometry/microscopy (multicolor, multiple cell types), animal models (injection, bleeding, organ processing) are preferred.
We are following NIH's postdoc salary guidelines.
UNC-Chapel Hill is situated between the Blue Ridge Mountains and the NC Beaches, close to Durham, Raleigh, and Research Triangle Park. It has an excellent, collaborative research environment.