Postdoctoral Fellow

Brigham and Women's Hospital

Boston, MA

Job posting number: #7062232

Posted: November 7, 2019

Application Deadline: Open Until Filled

Job Description

A postdoctoral position is available for a highly motivated individual to study the molecular genetics of skeletal and cardiac muscle physiology in the laboratory of Dr. Ronald Neppl’s laboratory at Harvard Medical School and Brigham and Women’s Hospital. Research in the laboratory is focused on understanding how non-coding RNAs modulate the cellular and molecular mechanisms underlying muscle homeostasis and the progression of disease. Current research projects within the lab investigate 1) the role of novel lncRNAs in skeletal muscle physiology, including hypertrophy and regeneration, 2) the role of aging on fibrotic paracrine signaling, and 3) the role of alternative splicing in modulating skeletal muscle metabolism. Recent Ph.D. graduates in molecular and cell biology, systems biology/physiology, or related biomedical sciences are encouraged to apply. Prior experience in small animal surgeries is a plus.

Candidates who are interested in any of these three research projects should send a CV and contact information to Dr. Neppl at Brigham and Women’s Hospital is an equal opportunity employer.

Principal Duties And Responsibilities
• The specific project will be finalized in consultation with the fellow. Considerable latitude will be given to the fellow to develop their own strategy for addressing questions of mutual interest. In general, the fellow should be highly motivated, able to think critically and capable of carrying the primary responsibility for an independent project.
• The candidate will utilize novel mouse genetic models, next generation RNA sequencing, traditional cellular and molecular biological techniques, and gene therapy approaches to uncover the pathogenesis of muscle dysfunction. It is anticipated that new findings will help uncover the mechanisms underlying muscle atrophy and the progression of myocardial remodeling with advancing age. Developing the ability to analyze molecular pathways that underlie observed physiological profiles of connectivity is of particular interest.
• A strong physiology and signal transduction background as well as familiarity with basic molecular biology techniques will be essential.

Highly motivated applicants with PhD or MD, working knowledge of skeletal or cardiac muscle physiology, molecular biology, or a related field, and a strong interest in skeletal and cardiac muscle function in health and disease are encouraged to apply.

Skills/Abilities/Competencies Required
• Strong prior experience in cardiac and/or skeletal muscle biology, animal models of disease, and/or molecular biology is required.
• Strong prior experience in immunohistochemistry, light and confocal microscopy, PCR methods, molecular cloning, and ChIP is preferred.
• Basic background in molecular biology techniques, Western blot analysis, viral injections, and mouse genetics is desired.
• Only highly motivated individuals with a deep desire to understand muscle functionality and the cellular and molecular levels will be considered.

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