Postdoctoral Scholar for the Study of Gene Regulatory Networks Controlling Cardiac Rhythm, Function, and Disease

University of Chicago

Chicago, IL

Job posting number: #7062376

Posted: November 15, 2019

Application Deadline: Open Until Filled

Job Description

What are the genomic principals of the gene regulatory networks that control cardiac
rhythm and function in the adult heart? How do perturbation of these networks cause
arrhythmias or heart failure? Can we define pathologic networks specific to disease
and intervene to improve cardiac rhythm or heart function?

Applications are invited for postdoctoral positions for research and training in the
Moskowitz laboratory at The University of Chicago to investigate these questions
(http://moskowitzlab.uchicago.edu/index.html). We seek a motivated and well-trained
individual to join a NIH funded investigation of the gene regulatory networks controlling
heart rhythm and arrhythmias (https://elifesciences.org/articles/31683 and
https://stm.sciencemag.org/content/8/354/354ra115). We have pioneered a novel
approach for identification of functional enhancers and associated long non-coding
RNAs (lncRNAs). We will investigate the gene regulatory networks controlling cardiac
rhythm and function, and define the molecular mechanisms underlying cardiac
arrhythmias and heart failure that result from network dysfunction. These novel
approaches are applicable to human genetics, transcriptional regulation, and RNA
biology, and will impact cardiovascular genetics and human molecular
genetics more broadly. The laboratory integrates genomics, bioinformatics, molecular biology, mouse genetics, human genetics, and embryonic stem cell differentiations to investigate basic principles of gene regulation in the context of the adult heart.

Our laboratory is affiliated with the Departments of Pediatrics, Pathology, and Human
Genetics, the Institute for Genomics and Systems Biology (http://www.igsb.org), and
graduate programs in both Development, Regeneration and Stem Cell Biology
(https://drsb.uchicago.edu) and Genetics, Genomics and Systems Biology
(https://ggsb.uchicago.edu). We are located in the Knapp Center at the University of
Chicago.

Highly motivated candidates with a recent PhD in developmental biology, molecular
biology, genetics, pathology, cardiology or related fields and with at least one first author paper in an English language journal are encouraged to apply. Experience with
genomics, molecular biology, mouse genetics, and/or bioinformatics is sought.
Molecular biology skills are essential. Please send a letter describing research
experience/interest, CV, and contact information for three references electronically to:
cpaez@peds.bsd.uchicago.edu.

Please address correspondence to:
Ivan Moskowitz, M.D., Ph.D.
Professor and Vice Chair for Research
Departments of Pediatrics and Pathology
The University of Chicago
900 East 57th Street, KCBD Room 5102
Chicago, Illinois 60637

Key words: Genetics, Genomics, Heart, Cardiac, Cardiac Rhythm, Arrhythmia, Atrial Fibrillation, Cardiac Function, Heart Failure, electrophysiology, RNA, non-coding RNA, long non-coding RNA, lncRNA, cardiology, molecular mechanism, gene regulatory network

The University of Chicago is an Affirmative Action/Equal Opportunity Employer.





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Job posting number:#7062376
Application Deadline:Open Until Filled
Employer Location:The University of Chicago
Chicago,Illinois
United States
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