Associate Research Scientist

The Jackson Laboratory for Genomic Medicine

Farmington, CT

Job posting number: #7070087 (Ref:JAX27442)

Posted: September 20, 2020

Application Deadline: Open Until Filled

Job Description

Summary

Associate Research Scientist

Chuang Lab

 

Computational biology is critical not only to the processing and manipulation of data, but to the scientific discovery process itself. Our lab empowers computational biologists to make discoveries by providing a rich work environment for computational/mathematical analysis of biological systems, access to novel data and computational infrastructure, resources to conduct new experimental measurements, and partnerships with experimental colleagues with shared interests.

As of December 2019, the Chuang Lab is seeking a scientist to join our projects combining computational and experimental approaches to study cancer. This project is being considered primarily at the level of a postdoctoral fellow, but scientists with prior postdoctoral experience and relevant expertise may be considered at the associate research scientist level upon discussion. Our current projects are at the intersections of cancer biology, machine learning, genomics, image analysis, and pathology. This is a fast-moving field with tremendous opportunities to understand cancer and impact patient outcomes.

New team members will have unique opportunities to investigate mechanisms of cancer, to design new studies, and to develop novel artificial intelligence approaches to mine these data. Our lab seeks to understand how tumor ecology and evolution impact susceptibility and response to immunotherapy, targeted therapy, and chemotherapy. We interrogate these questions by generating data from clinical samples and model systems (xenografts, organoids) and by mining large cancer genomic and imaging datasets using techniques such as deep learning and evolutionary modeling. This position is supported by an R01 grant from the NCI awarded through 2023.

While our lab focuses on computational approaches, we also generate our own data by making use of the extensive scientific services at JAX and in collaboration with many experimental colleagues. These include clinical and experimental groups at JAX (Robson, Palucka, Liu, Anczukow-Camarda, et al.) and with external partners (NCI PDXNet, Yale, Northwestern, UCSD, et al). We have particular access to patient-derived xenografts (PDXs) due to Prof. Chuang's position as co-PI of the National Cancer Institute's PDXNet Consortium Data Commons and Coordination Center, in addition to the extensive data and experimental resources for PDXs at JAX. Thus candidates will have novel opportunities at the intersection of data interpretation, algorithms, and experimental design.

For this position, the ideal candidate will have Ph.D. experience in computational biology, cancer biology, evolutionary biology, digital pathology, or a similar discipline. Outstanding applicants new to computational biology will also be considered as the lab has an extensive record of training candidates who originally studied in other fields, including physics, applied math, computer science, electrical engineering, and experimental molecular biology. A particular area of growth for the lab is the combination of genomic and pathological analysis, and those with a medical background in pathology but a strong interest in computational approaches are encouraged to apply. Computing (programming, data analysis, statistical inference, etc), publication, and communication skills will be essential. Across these backgrounds, enthusiasm and aptitude for computational biology are what define the lab.


Qualifications

The ideal candidate will have Ph.D. experience in computational biology, molecular evolution, cancer genomics, or a similar discipline. Strong computing (programming, data analysis, statistical inference, etc.), publication, and communication skills are essential.  Enthusiasm and aptitude for computational biology are what define the lab.

 

Interested applicants should submit a CV and a research statement with their application. Reference letters will be requested subsequently.

About Us

The Jackson Laboratory (www.jax.org) is a nonprofit biomedical research institute with over 1,800 employees across three campuses nationwide. Our mission is to discover precise genomic solutions for human disease, and to empower the global biomedical community in the shared quest to improve human health.  JAX's research institute in Connecticut, The Jackson Laboratory for Genomic Medicine (JAX-GM), is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX-GM’s research focuses on the complex genetic causes of disease, and on the development of genomic solutions tailored to each person's unique genetic makeup.

 

JAX-GM sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians and support staff in state-of-the-art computing facilities and laboratories. Our employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients’ lives.

 

JAX-GM resides in the scenic town of Farmington, in the state’s capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns.  JAX-GM is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems including bus lines, highways, railroads and international airports.

 

Our Values:

 

INTEGRITY - Courage and commitment to do what is right

PEOPLE - Inspiring our people to enhance the health of all

ONE TEAM - Unified by our promise to transform medicine and science

EXCELLENCE - Achieving world-class results

INNOVATION - Leading with discovery and creative solutions

STEWARDSHIP - Caring for and enhancing the resources entrusted to us

 

What do we have to offer?

                                                                                                                            

JAX offers a dynamic and supportive work environment, competitive salaries and a comprehensive benefits package including a medical plan, outstanding retirement plan, generous paid time off and tuition reimbursement.  JAX offers an MBA program, a fitness center with an award winning wellness program, and a fully operational primary care facility available to employees and their families.

 

Most importantly, every position contributes to JAX’s mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health.

 

 

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.

 

Learn more about at opportunities at JAX at http://www.jax.org/careers





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