Postdoctoral Fellow – GPCR Drug Discovery

H. Lee Moffitt Cancer Center

Tampa, FL

Job posting number: #7070249 (Ref:hlj_27406)

Posted: September 24, 2020

Application Deadline: Open Until Filled

Job Description

Dr. Patricia McDonald  is seeking to hire a highly motivated and independent postdoctoral fellow in the department of Cancer Physiology at the H. Lee Moffitt Cancer Center. Applicants interested in drug discovery projects aimed at validating novel anti-diabetic and anti-cancer GPCR drug targets and developing agents to modulate these receptors are encouraged to apply. 

Our laboratory is focused on investigating the molecular mechanisms underlying the regulation, trafficking, and activation of GPCRs involved in Metabolic disorders, and Cancer; with the goal of  identifying novel, tractable, anti-diabetes and anti-cancer GPCR drug targets, developing selective molecular probes of these targets and, where possible, optimizing these probes to generate in vivo lead molecules for testing in pre-clinical models, ultimately translating these findings into diabetes and cancer clinical trials.

Position Highlights:
•    The position is for a Postdoctoral fellow to join a multidisciplinary team to interrogate GPCR signal transduction pathways relating to diabetes,obesity and cancer aimed at identifying novel, tractable drug targets for the treatment of these diseases, and to contribute to our understanding of the metabolic disorder-cancer relationship.
•    Opportunity to gain drug discovery experience in collaboration with world-class clinical and basic science faculty.

The Ideal Candidate:
Successful cancdidates will have a strong background in signal transduction with a keen interest in drug discovery research. 
Prior experience is required with some of the following techniques: 
•    extensive experience with basic molecular and cell biology skills
•    extensive experience with mammalian cell culture
•    experience with immunofluorescence staining and multi parameter flow cytometery, sample preparation and  data aqcquistion
•    experience in animal models
•    Good problem-solving skills, ability to conduct independent research, ability to work effectively in a team

While experience in the above skills is highly preferred, applicants with related skills set are encouraged to apply. 

Credentials and Qualifications: 
•    Candidate is required to have a PhD in Molecular, Cellular, Chemical Biology, or relevant field.
•    We are looking for candidates who are new grads or have graduated within the past 2-3 years.
Moffitt is the only Florida cancer center to receive the National Cancer Institute designation for its scientific excellence and offers unique opportunities for interdisciplinary collaborations at the forefront of finding new cancer cures.

Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, a personal statement of scientific interests and goals, current CV with recent publications, and contact information for three references to Dr. Patricia McDonald at 

Mission To create a Moffitt culture of diversity and inclusion as we strive to contribute to the prevention and cure of cancer. Vision Moffitt Cancer Center is recognized as the model wherein the diversity of our employees and communities is valued and supported as essential components to contributing to the prevention and cure of cancer. The cancer center is an equal opportunity employer. It is the policy of the cancer center to prohibit unlawful discrimination and harassment of any type and to afford equal employment opportunities to workforce members and applicants, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, national origin, age, marital status, disability, genetic information, veteran’s status or any other characteristic protected by federal, state or local law.

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More Info

Job posting number:#7070249 (Ref:hlj_27406)
Application Deadline:Open Until Filled
Employer Location:H. Lee Moffitt Cancer Center
United States
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