Postdoctoral Fellow in Cancer Drug Discovery (Chemical Biology)

H. Lee Moffitt Cancer Center

Tampa, FL

Job posting number: #7075384 (Ref:hlj_29446)

Posted: February 23, 2021

Application Deadline: Open Until Filled

Job Description

The  Duckett lab is seeking to hire a highly motivated postdoctoral fellow in the department of Drug Discovery at the H. Lee Moffitt Cancer Center and Research Institute who wants to develop and apply cutting-edge technology for biomedical research in the growing field of small molecule-induced protein degradation. Our lab is pursuing highly multidisciplinary and collaborative research at the interface of molecular biology, functional genetics, medicinal chemistry and bioinformatics. 

The focus of the lab is identifying novel anti-cancer targets, developing, new selective molecular probes of these targets as tools to interrogate how their altered signaling drives tumor progression, metastasis, therapy resistance and mechanisms of immune escape. Using pharmaceutical practices, we aim to optimize these new probes as potential therapeutics. The successful candidate will be involved in an exciting new project to determine the mechanism underlying small molecule protein degraders and their application in anti-cancer research.

Position Highlights: 
•    The position is for a Postdoctoral fellow to join an interdisciplinary team to develop new agents designed to modulate targets previously considered difficult to drug  
•    Opportunity to gain drug discovery experience, conduct independent research in chemical biology and develop new compounds with novel mechanism of action to interrogate oncogenic signaling pathways. 

The Ideal Candidate:
Successful candidates will have a strong background in cancer biology with a keen interest in drug discovery research. 
•    Prior experience is required with some of the following techniques: 
o      mammalian cell culture.
o    experience in chemical biology techniques.
o    biochemistry/ enzymology.
o    drug discovery cell-based assay development. 
o    molecular and cell biology. 
o    experience in vivo mouse efficacy studies.  
•    excellent oral and written communication skills are required while experience in the above skills is highly preferred, applicants with related skills set are encouraged to apply.

Responsibilities: 
•    This individual will perform investigational studies using human cell lines, primary patient derived spheroids, and tumor samples. 
•    Designing and perform experiments independently and analyze data. 
•    Identify and validate targets from existing RNA seq and proteomic data sets. 
•    Perform experiments aimed at elucidating compound mechanism of action.
•    Participate in data interpretation and crafting manuscripts for publication.

Credentials and Qualifications: 
•    MD or PhD in chemical biology, molecular biology, biochemistry, or relevant field.
 
Moffitt is the only Florida cancer center to receive the National Cancer Institute designation for its scientific excellence and offers unique opportunities for interdisciplinary collaborations at the forefront of finding new cancer cures.

How to Apply: 
Interested applicants should include a single PDF file by email that includes:
(i)    a cover letter summarizing outlining candidate’s motivations and suitability 
(ii)    a summary of research accomplishments (4 pages maximum) 
(iii)    current CV with recent publications and contact information for three references 

For questions regarding the opportunity, please contact Dr. Derek Duckett’s office via email – Melissa.Meister@Moffitt.org.  
 



Mission To create a Moffitt culture of diversity and inclusion as we strive to contribute to the prevention and cure of cancer. Vision Moffitt Cancer Center is recognized as the model wherein the diversity of our employees and communities is valued and supported as essential components to contributing to the prevention and cure of cancer. The cancer center is an equal opportunity employer. It is the policy of the cancer center to prohibit unlawful discrimination and harassment of any type and to afford equal employment opportunities to workforce members and applicants, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, national origin, age, marital status, disability, genetic information, veteran’s status or any other characteristic protected by federal, state or local law.


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Job posting number:#7075384 (Ref:hlj_29446)
Application Deadline:Open Until Filled
Employer Location:H. Lee Moffitt Cancer Center
Tampa,Florida
United States
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