Scientist - Drug Discovery

The Wyss Institute for Biologically Inspired Engineering at Harvard University

Boston, MA

Job posting number: #7100365

Posted: May 18, 2022

Application Deadline: Open Until Filled

Job Description

About Us:
The Wyss Institute’s mission is to transform healthcare and the environment by emulating the way nature builds. We harness the freedom of academia and the focus of industry in order to translate revolutionary technologies into commercial products and solutions. At the Wyss Institute, faculty from premier academic and clinical institutions, collaborate with staff scientists, postdocs, graduate students, industry experts, business development leaders, and entrepreneurs across disciplines to invent and de-risk new technologies that don’t just succeed at making it to the market – they disrupt it. We support research that universities, companies, and venture capital firms don’t fund because they view it as too risky. We prefer to use the word “challenging,” and we love challenges. For more information, visit:

About You:
You are a collaborative, impact-focused problem solver who wants to be part of a dynamic team dedicated to creating and commercializing novel approaches to global challenges in healthcare. You are excited by the prospect of joining an effort that is close to commercialization and potentially becoming a member of a new spin-out company. You want the freedom to explore, to push the boundaries of what is possible, and to use your ambition to tackle challenging projects in a fast-paced, industry-focused environment without a lot of administrative hurdles. You have experience with the development of pharmaceuticals, biologics, gene therapies or in-vitro diagnostics and want to apply this knowledge to enable a drug development pipeline. You want to be involved in a wide range of cutting-edge technologies that have a high degree of technical rigor and creativity. You enjoy working with diverse groups of people and leveraging your expertise to create innovations that can change the world.

About the Role:
We are looking for an experienced, creative and entrepreneurial-minded Scientist to establish and lead assay development and validation efforts central to the advancement and pre-clinical translation of a therapeutic program that is close to commercialization. In this role, you will make significant contributions to the team’s efforts to develop a robust preclinical data package that will be used as the basis for a commercialization end-point, likely the spin-out of a new company. Reporting to a Senior Principal Scientist, and collaborating closely with cross-functional team members and Faculty, you will quickly learn important biological assays and contribute data in assays that will help support the exciting preclinical data package for this therapeutic asset. After coming up to speed and making important scientific contributions, you may have the opportunity to become a member of an exciting new company based on this asset and technology. As a member of the Advanced Technology Team, you will be exposed to many different technologies in areas ranging from therapeutics and diagnostics to synthetic biology and materials science, with the goal of identifying new product solutions and the unique opportunity to follow your passion either at the Institute or as a future co-founder of a Wyss start-up.

What you'll do:
Design experiments, analyze data and propose candidate acceptance criteria for testing and validation of candidate targets.
Develop cell-based, molecular, and biochemical methods for a pre-clinical discovery and validation program.
Contribute to a broader spectrum of drug discovery activities, including target ID/validation, or early discovery as aligned with scientific expertise & interests, workload and departmental priorities.
Transition pilot use of concept-stage methods to assay development.
Develop novel and robust methods for a wide range of cellular and molecular processes.
Provide technical excellence across multiple sets of analytical methods (e.g., enzyme assays, molecular assays, cell-based assays, signal transduction assays, etc.).
Write and review development documentation including protocols, test procedures for internal and external development work.
Design experiments, analyze data and propose candidate acceptance criteria for testing and validation of candidate targets.
Present key results at group meetings, project teams, and stakeholders.
Contribute to regulatory submission documents, internal document preparation, and scientific publications.
Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

What you'll need:
A Bachelor’s degree required in Biochemistry, Pharmacology, Biology, Genetics, Bioengineering or related field required.
A minimum of 4 years of experience in assay/analytical development required.

Desirable Skills:
PhD in Biochemistry, Pharmacology, Biology, Genetics, Bioengineering or related field is strongly preferred
Graduate training in Biochemistry, Pharmacology, Cell & Molecular Biology, Genetics, Bioengineering or related discipline and 4+ years industry experience in assay/analytical development required.
Direct experience with development of pharmaceuticals, biologics, gene therapies, or in vitro diagnostics required.
Demonstrated understanding of assay development principles and processes required.
Expertise with nucleic acid test development (ddPCR, qPCR, sequencing) required
Experience with cell culture, microscopy, biochemistry, molecular biology, cell-based functional assays.
Experience in authoring and critically reviewing technical documents, study protocols and reports related to assay development, qualification, validation, and clinical sample testing a plus.
Excellent written and verbal communication skills, documentation skills and attention to detail, with the proven ability to work effectively as a member of a multidisciplinary team
Excellent organizational skills, technical writing, record keeping and ability to manage multiple projects and the ability to be nimble and work in a fast-paced environment are crucial.
The successful candidate will be an ambitious self-starter, have a strong work ethic, be able to generate high-quality work under tight deadlines, and enjoy working in a fast-paced team environment.

Additional information: This is a one year term position with the possibility of renewal.

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More Info

Job posting number:#7100365
Application Deadline:Open Until Filled
Employer Location:The Wyss Institute for Biologically Inspired Engineering at Harvard University
United States
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