Summary

The overall goal of our research program is to delineate novel pathways that link hepatic metabolism and disease. Specifically, Wilson’s disease patients and animal models (such as Atp7b-/- mice) develop severe liver dysfunction and spontaneous hepatic nodule formation. We have several ongoing projects for this area: copper-mediated changes in nuclear receptor function, metabolism, liver regeneration/nodule formation, and autophagy.

Job Duties

• Independently maintain mouse colonies for experimentation.
• Perform research experiments, such as, chromatin immunoprecipitation (ChIP) and ChIP-Seq assays, RNA-Seq assays, Western blotting, and tissue culture.
• Document results and prepare them for presentation.
• Evaluate, analyze, and submit data to the PI.
• Prepare figures for publications, conferences, and grants.
• Help train junior staff and graduate students.
• Conduct literature searches and summarize information for the PI.
• Maintain lab equipment and inventory lists.
• Prepare buffers and reagents for laboratory operations.
• Genotyping and mouse colony management, Western blotting, PCR, real-time PCR, ChIP assays, CRISPR/Cas9 techniques.

Minimum Qualifications

• Master's degree in Basic Science or a related field.  Experience in lieu of degree will not be accepted.
• Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.

Preferred Qualifications

• Master’s of Science Degree in Biochemistry, Molecular and Cellular Biology, or related fields.
• Must have positive attitude and eagerness to learn new laboratory techniques.
• Should have excellent communication skills and work well with others.
• Knowledge of software programs including R and/or python are preferred but not required.