Job Description

The laboratory of Prof. Bin Liu at UCSF is seeking qualified individuals for postdoctoral fellow positions (up to 3) working on novel cancer target discovery and antibody therapy development.

What we do: (1) Target discovery - we select antibody gene diversity libraries on patient samples to probe the tumor cell surface epitope space and identify novel targets including conformational and post-translationally modified epitopes that are difficult to discover by gene expression analysis. (2) Antibody cancer therapy - we generate human monoclonal antibodies by phage and yeast display, and use them to construct antibody-drug conjugates, bispecific antibodies including bispecific T and NK cell engagers, and siRNA/mRNA delivery vehicles. Through collaboration, we are also developing radio-ligand therapy and engineered T cell for cancer treatment. (3) Translation to the clinic - a primary goal of our research is to translate laboratory finding into clinical trials. We have identified several novel cancer targets, developed a number of therapeutic agents including antibody-drug conjugates and bispecific antibodies (PMCID: PMC6171802, PMC5127683, PMC7572689, PMC8594452, PMC7925362, PMC5768681, PMC6548581), and translated a portion of these lab discoveries into 4 clinical trials, three in cancer therapy (NCT03575819, NCT03650491, NCT05011188) and one in PET imaging (NCT05245006).

What we seek: Candidates with Ph.D. or M.D./Ph.D. and track records of accomplishment in one of the following areas: (1) Antibody engineering and protein chemistry, with skills applicable to multi-functional and multi-specific antibody development; (2) Bioconjugation chemistry, with knowledge and skills to create novel antibody-drug conjugates and nanoparticles for nucleic acid delivery; (3) Antibody discovery by phage or yeast display, and target discovery by immunoprecipitation and mass spectrometry; (4) Cell engineering and immunology, with knowledge and skills to develop cell therapy and explore immune cell reprogramming in vivo.

How to apply: Interested individuals please submit (1) a curriculum vitae, (2) a short description of research background and accomplishment, and (3) contact information of three references.