Research Associate I – Aging mice, interventions and tissue pathology
San Diego, CA
Job posting number: #7111119 (Ref:spd-2120045)
Posted: September 20, 2022
Application Deadline: Open Until Filled
SBP is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health.
A Research Associate I position (depending on qualifications) is available in the laboratory of Dr. Peter Adams.
Non-proliferating, pro-inflammatory senescent cells accumulate in aged tissues and are known to promote tissue aging and disease. Dr. Adams is leading a Tissue Mapping Center (TMC), in collaboration with Dr. Bing Ren UCSD, as part of the NIH SenNet Consortium (https://commonfund.nih.gov/senescence), the goal of which is to qualitatively and quantitatively map the distribution of senescent cells in mouse tissues across the mouse lifespan. This is a highly collaborative project, both between Adams, Ren and other labs in San Diego and other mouse and human TMC sites across the US. The San Diego TMC will employ state-of-the-art single cell spatial and dissociative transcriptomics and epigenomics approaches, such as MERSCOPE and Nanostring CosMx, and sophisticated data analysis and integration, to generated a landmark spatial atlas of senescent cells across the mouse lifespan. The Adams lab is seeking a Research Assistant with expertise in mouse husbandry and drug interventions, mouse anatomy, mouse tissue harvests and basic histopathology, and analysis, for example by immunofluorescence, immunohistochemistry and in situ hybridization. There will be tremendous opportunities to learn state-of-the-art biological concepts and techniques, in a collaborative, dynamic and exciting research environment.
For additional information on the lab see http://www.padamslab.org and twitter - @AdamsBioAging and UCSD Center for Epigenomics https://medschool.ucsd.edu/som/cmm/research/epigenomics/Pages/default.aspx
Salary Range: $55K - 62K annually
- Mouse husbandry and drug interventions.
- Mouse anatomy, tissue harvests and basic histopathology.
- Tissue analysis, for example by immunofluorescence, immunohistochemistry, in situ hybridization, qPCR and Western blot.
- Manage project workflow from conceptualization to live mice and interventions to tissue harvests and analysis in electronic form, to facilitate data storage, retrieval and exchange with collaborators.
- Keep written records of experiments and data organization
- Troubleshoot problems and develop solutions to technical problems of moderate to high scope using independent thinking, literature, and colleagues as resources to solve problems
- Provide interpretation and analysis of results
- Present results and project progress to other lab members informally and at weekly lab meetings, and also to other members of San Diego TMC and SenNet.
- Maintains various reagent collections, and inventories
- Orders lab supplies as needed
- Bachelor’s degree or higher in a biological science, chemistry or related field
- Specific training and expertise in mouse husbandry and drug interventions, mouse anatomy, mouse tissue harvests and pathology, and analysis, for example by immunofluorescence, immunohistochemistry, in situ hybridization, qPCR and Western blot.
- Expertise with multiplex spatial -omics and/or single cell transcriptomics and epigenomics is a plus.
Knowledge, Skills and/or Abilities
- Work independently as well as in a team environment
- Manage project workflow from conceptualization to completion, to facilitate data storage, retrieval and exchange with collaborators.
- Be responsible and have strong time management skills
- Able to analyze and resolve issues of moderate complexity
- Possess strong attention to detail and organizational skills
- Demonstrate professional communication and interpersonal skills
- Professional proficiency in Microsoft Office
- Embody the Institute’s core values of Commitment, Collaboration, Communication, Community and Compassion
The scientists at Sanford Burnham Prebys Medical Discovery Institute are making research breakthroughs in cancer, neuroscience, immunology, and children's disease. We are also at the forefront of finding solutions for emerging health threats such as COVID-19, where we are working to identify drugs that may help millions of people. During our more than 40 year history, we have established an NCI-designated Cancer Center, designed one of the most sophisticated drug discovery centers in the nonprofit world, and created global collaborations that are leading to preventions, treatments and cures to improve human health.
Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity Employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE.