Senior Associate Scientist - Early Bioprocess Development, Vaccines R&D

Pfizer Inc.

South San Francisco, CA

Job posting number: #7117211 (Ref:4873158 Senior Associate Scientist - Early Bioproc)

Posted: December 2, 2022

Application Deadline: January 3, 2023

Job Description

Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve
As a Senior Associate Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will assist with development and qualification of bioanalytical methods in support of characterization, toxicology and stability studies for bioprocess and formulation development of early phase vaccines.

Your significant experience of applying knowledge of principles, concepts, and practices of the discipline will make you a critical member of the team. You are proactive in contributing to all team discussions and creating an environment of collaboration.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

Contribute to achievement of immediate work group goals and may undertake collaborations with other team members.

Gather inputs from colleagues, literature, and additional resources to assist in driving the project forward.

Assist with the development of robust and reliable ligand binding and cell-based assays suitable for characterizing the disposition and Immunogenicity of biotherapeutics in various matrixes using a range of potential platforms and assay techniques.

Advance bioanalytical capabilities to improve efficiency, cost effectiveness and appropriateness of assay for discovery and development stage assets.

Deliver concentration and immunogenicity data to Pharmacokinetics, Dynamics & Metabolism (PDM) BioTX principal investigators and other partners.

Perform data analysis and interpretation and draw conclusions regarding progress and results of work, utilizing the data for appropriate decision making.

Ensure Good Laboratory Practices {part of GxP} compliance is maintained in laboratory during study support.

Author technical documents, e.g. Standard Operating Procedures, data summary reports and Bioanalytical procedures.

ROLE SUMMARY

This individual will be responsible for supporting analytical characterization of viral vaccine strain change activities within the Vaccine Research and Development – Early Bioprocess Development group. The candidate will assist with the analytical team to support the RNA drug substance, LNP drug product, and critical reagent production and characterization to enable strain changes as required. The individual will provide scientific and technical support for the team of analytical scientists, as well as work with multifunctional teams outside of their reporting structure.

ROLE RESPONSIBILITIES

Effectively execute analytical protocols for release and characterization of RNA drug substance, LNP drug product, and critical reagents to support viral vaccine strain change.

Analyze data obtained with minimal supervision.

Document experiments contemporaneously in either an electronic or paper notebook as directed and provide to supervisor or designee for review.

Contribute to authoring technical documents including development reports, analytical test methods, and method qualification reports.

Perform other duties as assigned. This includes maintaining laboratory instruments as necessary according to applicable guidelines and ordering frequently used reagents and materials.

Read scientific and technical literature to stay current in the field and to bring new and improved technologies to the laboratory.

Qualifications
Must-Have

BS degree in biology or related discipline with 3+ years relevant experience, MS degree with 0+ years of relevant experience

A strong background in biochemical and immunological techniques is essential.

Proficiency with personal computers including word processing, spreadsheets, PowerPoint and relevant scientific software is required.

Strong verbal and written communication skills

Preferred Qualifications
Previous experience with developing immunoassays for detecting proteins or glycoconjugates is desired.

Experience with protein purification, cell transfection, Flow Cytometry, and cell culture in a BSL2 environment is a plus.

Experience with documentation of laboratory notebook in an electronic format is desired

PHYSICAL/MENTAL REQUIREMENTS

Standard laboratory conditions – sitting, standing, primarily lab based

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

40 hours per week.


Work Location Assignment: On Premise

Other Job Details:

Eligible for relocation package

Eligible for employee referral bonus


Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.


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More Info

Job posting number:#7117211 (Ref:4873158 Senior Associate Scientist - Early Bioproc)
Application Deadline:2023-1-3
Employer Location:Pfizer Inc.
New York,New York
United States
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