Dir. Automated Patch-clamp

Harvard Medical School

Boston, MA

Job posting number: #7119322 (Ref:hh-61056BR)

Posted: January 4, 2023

Application Deadline: Open Until Filled

Job Description

Position Description
Direct a drug discovery project using high-throughput automated patch clamp technology to identify new drug candidates targeted to voltage-dependent ion channels to treat pain, epilepsy, and other neurological disorders. Work with medicinal chemists in the HMS Therapeutics Translator to select and construct curated compound libraries suitable for high-throughput screening and work with the ICCB-Longwood screening core to develop an effective screening strategy using high-throughput compound handling technology. Train other scientists in the effective use of high-throughput patch clamp technology for drug screening in other projects. The Director of Automated Patch-clamp Drug Discovery will also oversee data management and data analysis of the large volume of data generated by the electrophysiological screening and will work with medicinal chemists on strategies for iterative design of new molecules based on the structure-activity data. They will also be responsible for preparing reports and analysis to be used in patent applications and will work with the Office of Technology Development to develop strategies for commercializing the drug candidates. They will also interface with collaborating laboratories and Contract Research Organizations to design effective in vivo behavioral testing of drug candidates resulting from the screening. The candidate will be a scientific leader in the project.
Basic Qualifications
Candidates should hold a Ph.D. in neurobiology, physiology, pharmacology, biophysics, or a related field and at least 8 years of experience in research or drug development using electrophysiological techniques.
Additional Qualifications and Skills
  • Industry experience in developing drugs targeted to ion channels using high-throughput patch clamp technology
  • Knowledge of biophysics of voltage-dependent gating of neuronal sodium, calcium, and potassium channels
  • Experience with designing high-throughput screening strategies
  • Experience with collaboration with medicinal chemists to iteratively design and test novel compounds
  • Experience with intellectual property considerations in drug design and commercialization
  • Salary commensurate with expertise and previous accomplishment
Additional Information
This is an in-person position based on our campus in Boston.

This is a 12-month term appointment with the possibility of renewal contingent on funding.

The University requires all Harvard community members to be fully vaccinated against COVID-19 and remain up to date with COVID-19 vaccine boosters, as detailed in Harvard’s Vaccine & Booster Requirements. Individuals may claim exemption from the vaccine requirement for medical or religious reasons. More information regarding the University’s COVID vaccination requirement, exemptions, and verification of vaccination status may be found at the University’s “COVID-19 Vaccine Information” webpage: http://www.harvard.edu/coronavirus/covid-19-vaccine-information/

Please note that we are currently conducting a majority of interviews and onboarding remotely and virtually. We appreciate your understanding.

Harvard University offers an outstanding benefits package including:
  • Time Off: 3 - 4 weeks paid vacation, paid holiday break, 12 paid sick days, 12.5 paid holidays, and 3 paid personal days per year.
  • Medical/Dental/Vision: We offer a variety of excellent medical plans, dental & vision plans, all coverage begins as of your start date.
  • Retirement: University-funded retirement plan with full vesting after 3 years of service.
  • Tuition Assistance Program: Competitive tuition assistance program, incredibly affordable classes directly at the Harvard Extension School, and discounted options through participating Harvard grad schools.
  • Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.
  • Wellness options: Harvard offers programs and classes at little or no cost, including stress management, massages, nutrition, meditation, and complementary health services.
  • Harvard access to athletic facilities, libraries, campus events, and many discounts throughout metro Boston.
The Harvard Medical School is not able to provide visa sponsorship for this position.
Commitment to Equity, Diversity, Inclusion, and Belonging
We are committed to cultivating an inclusive workplace culture of faculty, staff, and students with diverse backgrounds, styles, abilities, and motivations. We appreciate and leverage the capabilities, insights, and ideas of all individuals. Harvard Medical School Mission and Community Values
EEO Statement
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.

Harvard Medical School strives to cultivate an environment that promotes inclusiveness and collaboration among students, faculty and staff and to create new avenues for discussion that will advance our shared mission to improve the health of people throughout the world.

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More Info

Job posting number:#7119322 (Ref:hh-61056BR)
Application Deadline:Open Until Filled
Employer Location:Harvard Medical School
United States
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