Associate Scientist, Viral Vaccines - Entry Level

Pfizer Inc.

South San Francisco, CA

Job posting number: #7121834 (Ref:4870314 )

Posted: January 23, 2023

Application Deadline: February 24, 2023

Job Description

Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve
As an Associate Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will have the important role to generate high-quality immunoassay data in a regulated Good Laboratory Practices (GLP) setting to support Pfizer’s vaccine programs according to Standard Operating Procedures. You will have the important role in generating and characterizing viruses in support of the Influenza and SARS-CoV-2 vaccine program. In addition, you will also support throughput activities and provide testing support for clinical and non-clinical research programs.

Your strong foundation in general scientific practice, its principles and concepts will help in meeting critical deadlines. It is your hard work and focus that will make Pfizer ready to achieve new milestones and help patients across the globe. Your strong foundation in general scientific practice, its principles and concepts will help in meeting critical deadlines. You will be relied on as a technical contributor to assess the assigned tasks and make decisions that involve direct application of your knowledge. It is your hard work and focus that will make Pfizer ready to achieve new milestones and help patients across the globe. The Associate Scientist will be responsible for supporting viral production under BSL-2 and BSL-3 conditions in support of the Influenza and SARS-CoV-2 strain change program.

How You Will Achieve It
Exercise and build basic team effectiveness skills {e.g., commitment, feedback, consensus management} within the immediate work group.

Perform job responsibilities in compliance with current Good Manufacturing Practices/ Good Laboratory Practice (cGMP/GLP) and all other regulatory agency requirements.

Grow cells and generate viruses

Run Flow Cytometry assays on cell lines

Extract viral RNA and run qPCR assays

Assist in updating and writing documents associated with bio-functional assays, including information/data archiving, Standard Operating Procedure and status reports.

Assist in ordering supplies from internal inventory and prepare reagents/supplies necessary for bio-functional assay work, sssisting with the CRIIS system for tracking virus inventory and virus disbursements

Perform the bio-functional immunological assays (ELLA, NAI, IL-10 bioactivity) to support vaccine development

Supporting cell culture, virus infections, virus characterization (titrations, HA, ELLA, NAI, IL-10 bioactivity) and immunological assays (ELISA, ELISPOT and Flow Cytometry)

Supporting the sequencing of all viruses produced in the Viral Vaccines group and assist with qPCR required the hamster challenge model for SARS-CoV-2

Conduct clinical assays in accordance with Good Clinical Laboratory Practice (GCLP) requirements.

Present progress on assay development and sample analysis to colleagues and senior management.

Collect and analyze data on a per project basis to support troubleshooting, qualification and other lab projects.

Provide critical data review of clinical and non-clinical data.

Execute sample testing and analysis for toxicology and clinical trials.

Working collaboratively with other groups within Vaccines Research and Development including Early Bioprocess Development, the clinical testing group, and the Flow Cytometry group.

Stay current on all departmental and corporate training.

Bachelor's Degree in Biology, Biochemistry, Molecular Biology, Biomedical Engineering or relevant field of science

Laboratory experience in a relevant field of science

Strong attention to detail and ability to collaborate and work in team environment

Good Computer skills including word processing, Excel, PowerPoint and relevant scientific software

Pharmaceutical and biotech drug discovery experience

Cell culture experience

Flow Cytometry, ELLA, ELISA, ELISPOT

Aseptic techniques

Experience in developing and troubleshooting bioassays designed to assess antibody functionality

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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