Baylor College of Medicine
Job posting number: #7128048 (Ref:15084-en_US)
Posted: March 15, 2023
Application Deadline: Open Until Filled
Dr. Yingbin Fu's laboratory at Baylor College of Medicine (BCM) is seeking a talented post-doctoral fellow. The Fu lab is interested in using the visual system to study angiogenesis, cholesterol metabolism, inflammation, and the biological mechanisms underlying various types of neurodegeneration, and to develop innovative treatment strategies. The Fu lab has made significant contributions toward the understanding of the role of a multifunctional serine protease HTRA1 in age-related macular degeneration (AMD), the pathogenesis of polypoidal choroidal vasculopathy (PCV, a variant of wet type AMD), and the role of cone opsins in cone photoreceptor degeneration. Our recent research includes the following projects: 1) the role of the apolipoprotein-A-I binding protein (AIBP) in AMD; 2) the mechanism and treatment strategies for anti-VEGF resistance in wet AMD; 3) lipid metabolism and AMD, and 4) generating novel models of photoreceptor degeneration for regenerative cell therapy (NIH U24 project). Our recent studies have identified a mechanism for anti-VEGF resistance in wet AMD and developed the first potential AIBP/apoa-I/anti-VEGF combination treatment to overcome anti-VEGF resistance (PCT/IB2021/055463 patent pending).The PI has won the National Institute of Health/National Eye Institute Audacious Goals Challenge Awards (https://rebrand.ly/nih-award1; https://rebrand.ly/nei-award1). The candidate is expected to develop a highly innovative and effective treatment for AMD by targeting its multiple underlying causes including cholesterol metabolism, angiogenesis, inflammation, etc. The lab uses the following techniques for this study: histopathology on animal models and human specimens, transcriptome profiling, advanced in vivo imaging in animal models, gene therapy, drug delivery, etc. We place emphasis in Translational Research-- discovering disease mechanisms and developing innovative treatment strategies. Due to the translational nature of our research, students and postdocs will have good employment opportunities in both academia and industry.
- Plans, directs, and conducts research experiments including in vivo imaging, drug delivery, etc.
- Summarizes research findings and publish results in research journals.
- Supervises research staff.
- MD or Ph.D. in Basic Science, Health Science, or a related field.
- No experience required.
- Prior experience in the following areas is preferred: histopathology, transcriptome profiling, advanced in vivo imaging in animal models, gene therapy, and drug delivery.
- Recipients of recent PhD or MD degree are strongly encouraged to apply.
Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.