Baylor College of Medicine
Job posting number: #7134591 (Ref:15098-en_US)
Posted: March 17, 2023
Application Deadline: Open Until Filled
The Echeverria laboratory studies molecular evolution of triple negative breast cancer (TNBC) therapy resistance and metastasis. The focus of the lab is to delineate the metabolic and molecular evolution of TNBC using state-of-the art patient-derived xenograft mouse models and in vitro mouse- and patient-derived organoids. The lab utilizes functional genomics approaches, single-cell technologies, multiplexed tissue imaging, and metabolomics with the ultimate goal of combating tumor evolution to improve the lives of women living with TNBC.
We are seeking highly self-motivated individuals to provide research support, technical assistance, and lab organization. The laboratory’s work involves cell lines and state-of-the-art mouse models.
Projects include dissection of the molecular underpinnings tumor cell-microenvironment interactions as they pertain to therapy resistance and metabolic adaptations of therapy-resistant tumor cells, as well as single cell analyses of primary and metastatic TNBCs.
- Prepares and conducts laboratory research experiments involving mice, mammalian cell culture and molecular biology.
- Collects, compiles and analyzes data.
- Conducts literature searches and summarizes information in an appropriate format for a particular study.
- Selects, evaluates and applies techniques used in routine research.
- Orders laboratory supplies.
- Completes Goods Receipt via SRM/SAP.
- Plans and organizes administrative operations of the laboratory.
- Communicates with facilities, cores, EH&S and vendors within and outside of BCM to ensure smooth running of the laboratory.
- Participates in the development of laboratory grant budgets; the overseeing of expenditures of grant monies; performing SAP/SRM functions.
- Interprets rules, regulations, and policies for faculty and laboratory staff and ensures compliance.
- Coordinates procurements of equipment and supplies and manages all stages of the acquisition cycle.
- Establishes procedures for management of the use of laboratory equipment including maintenance, repair, and inventory.
- Manages receipt and shipping samples in accordance with various IRB protocols and shipping regulations.
- Assists with onboarding of new laboratory members.
- Bachelor's degree in a Basic Science or related field. Four years of related experience may substitute for degree requirement.
- Five years of relevant experience, with prior supervisory experience.
- Cancer research preferred.
- Experienced in mouse husbandry and maintenance of mouse breeding colony.
- Prior experiences in tissue culture and basic molecular biology techniques (e.g., PCR, DNA purification, Western blot, DNA/RNA/Protein manipulation from cell line/tissue/Blood… etc) are required.
- Must be a team player and work well within a group.
- The individual should be self-motivated and enjoy being highly organized, detail-oriented, communicative, and collaborative. The individual should enjoy contributing to ensuring the smooth and efficient operation of the laboratory. The lab provides an interactive and stimulating scientific environment and opportunities for growth.
Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.