Scientist Secondary Pharmacology
Pfizer Inc.
Groton, CT
Job posting number: #7136986 (Ref:pf-4881501)
Posted: March 29, 2023
Application Deadline: Open Until Filled
Job Description
Role Description
As a Scientist in the Secondary Pharmacology group, you will be responsible for supporting drug discovery by implementing and troubleshooting in vitro experiments to assess the off-target pharmacology of novel compounds using both cellular and biochemical assays.
Responsibilities
Work independently and as part of a team to help design, execute, analyze / interpret data generated from experiments from in vitro cell based assays. Specific duties to include:
- Apply scientific knowledge in running early in-vitro safety screening assays (384 well plate based; medium throughput) using a range of in vitro cell based, enzyme assays and transporter assays.
- Support screening efforts by performing aseptic cell culture work for multiple cell lines.
- Maintain detailed experimental records and prepare study summaries and technical reports.
- Have a working knowledge of analysis tools such as Excel, GraphPad, Biobook and PowerPoint for experimental documentation and data analysis/presentations.
- Contribute to building an innovative culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and in vitro expertise; take a proactive role in personal growth and scientific development.
Basic Qualifications
- Bachelor's degree plus 6 years' laboratory experience in Cell Biology, Biochemistry or Pharmacology (or related field).
- Previous experience running cell/enzyme-based assay platforms in a medium throughput environment. Experience using plate-based instrumentation (liquid handling, fluorescent plate readers, plate-based scintillation counters
- Cell culture experience
- Strong basic mathematical skills and ability to calculate dilutions on the fly.
- Eagerness to learn new laboratory techniques
- Ability to work in fast paced environment and meet aggressive deadlines.
- Strong organizational, interpersonal and communication skills as well as ability to perform tasks with minimal supervision. Team player attitude and strong work ethic is a must.
- Excellent time-management skills and ability to follow pre-established experimental designs, as well as ability to develop new protocols and methods with aptitude to troubleshoot problems in an independent manner.
Preferred Qualifications
- Master’s degree plus 4 years' laboratory experience in Cell Biology, Biochemistry or Pharmacology (or related field). Experience in pharmacology or drug discovery is highly desirable.
- Experience with the following platforms: FLIPR, Agilent BRAVO, Sophion QUBE, PerkinElmer EnVision, Microbeta radiometric plate reader, Nanion Cardioexcyte 96, PerkinElmer Signals.
- Experience working with hIPSC Cardiomyocytes (extended culture and use in assays).
PHYSICAL/MENTAL REQUIREMENTS
Ability to lift 20 lbs.
Ability to perform mathematical calculations.
Work Location Assignment: On Premise
Relocation assistance may be available based on business needs and/or eligibility.
Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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