Job Description

Role Summary

We are looking for a Scientist whose work will focus on RNA biochemistry and structural investigation for the Upstream Development Group within Early Bioprocess Development at VRD in Pearl River, NY. The incumbent will work with the upstream mRNA drug substance team to support various molecular biology and RNA biochemistry efforts. A comprehensive, hands-on background in all aspects of molecular biology is required, including in vitro transcription, RNA biochemical and structural analysis, molecular cloning, and plasmid construction. There would be particular interest in candidates with a background in NGS-based RNA analysis. The incumbent would join a team of scientists well-versed in mRNA production and characterization and would be expected to support and innovate efforts on multiple fronts.

ROLE RESPONSIBILITIES

The primary responsibility would be to support efforts in molecular biology and RNA biochemistry/structure work in the group. The incumbent should understand all aspects of molecular biology, including plasmid design, biochemical and structural assays for RNA, and nucleic acid characterization for quality and purity. In addition to the above, the ideal candidate would have hands-on experience performing and analyzing nucleic acid sequencing in the context of RNA structural tools, i.e., SHAPE or other affiliated techniques. As well as working with the mRNA team, the incumbent will be working closely with several other teams within and outside of VRD and leading innovation efforts on their own. Data documentation will be performed promptly and compliant, and data presentation will occur within the group, to project teams and at the departmental level.

BASIC QUALIFICATIONS

Master’s Degree with minimum of 6 years relevant experience or Bachelor’s Degree with minimum of 8 years relevant experience
Deep knowledge of varied aspects of molecular biology and RNA biochemistry
Experienced in the design and production of plasmid DNA and other forms of in vitro transcription templates
Command of analytical techniques such gel/capillary gel electrophoresis, fragment analyzer, nucleic acid analysis (Sanger, NGS, Nanopore, etc.)
Ability to design, organize and execute complex experiments
Ability to plan experimental workflows for multiple experiments
Ability to work independently
Collaborates in a team environment
Compiles, organizes and evaluates data
Has experience in preparing making comprehensive presentations