Senior Principal Scientist, Medicinal Chemistry
Job Description
ROLE SUMMARY
Our Internal Medicine (IM) Medicinal Chemistry Group delivers scientific excellence in the small-molecule medicinal chemistry portfolio aligned to the IM Research Unit (IM RU). You will work within the IM Medicinal Chemistry Design Group and will contribute to the medicinal chemistry effort on projects, in collaboration with the IM Research Unit and IM Medicinal Chemistry Synthesis Group. As the design chemist, you will drive a strong scientific agenda by utilizing available design tools to generate design hypotheses and contribute to target design.
You will play a vital role as leader of, or key contributor to, large, multi-disciplinary, matrix teams from project inception to delivery of clinical drug candidates. You will also lead, or provide key contributions to, teams of scientists looking to revolutionize our approach to the discovery and development of small-molecule and synthetically-derived drugs by combining Pfizer’s expertise and large-scale research investments with external academic and biotech collaborations.
KEY RESPONSIBILITIES
Drive a strong scientific agenda and the application of expert data analysis and contemporary design tools to drive effective target design and prioritization within a portfolio of projects
Contribute to medicinal chemistry strategy and devising hit identification strategies to move projects through the Hit-to-Lead phase with scientific excellence, efficiency, and speed
Play a key role in progressing projects through the Lead Optimization phase in partnership with enabling functions within Medicine Design, including Structural Biology; Chemical Biology; Primary Pharmacology; and Pharmacokinetics & Drug Metabolism, to ensure the delivery of small-molecule/synthetic drug candidates with scientific excellence, efficiency, and speed
Partnership with enabling functions across Pfizer, including Drug Safety, formulations, and process chemistry to drive project advancement to the clinic.
Contribute to the identification of new small-molecule projects and their entry to the portfolio through collaborations with disease area biologists
Play a role in enhancing the external reputation of Pfizer’s Medicinal Chemistry, Molecular Design, and synthetic Drug Discovery capabilities through publications and presentations at leading conferences
Promote and evaluate the application of novel approaches, methods, and modalities to the drug discovery process
Work with local Medicine Design leadership to put an active program of self-development in medicinal chemistry skills in place
BASIC QUALIFICATIONS
Ph.D. degree in Organic/Medicinal Chemistry or related area of science
Minimum 5 years related medicinal chemistry experience in the biopharmaceutical industry
Track record of delivering high impact contributions to medicinal chemistry projects
Expert working knowledge of the key medicinal chemistry concepts and design tools required for pharmaceutical drug discovery
Consistent record of peer-reviewed publications from scientific work to date
PREFERRED QUALIFICATIONS
Examples of high-impact publications in the field of Medicinal Chemistry/Drug Discovery
Experience leading matrix teams of scientists to deliver defined project objectives
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Requires occasional travel to Pfizer site in Groton, CT
Relocation support available
Work Location Assignment: On Premise
The annual base salary for this position ranges from $117,300.00 to $195,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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