Principal Scientist, Medicinal Chemistry

Pfizer Inc.

Cambridge, MA

Job posting number: #7231489 (Ref:pf-4908435)

Posted: March 25, 2024

Job Description

ROLE SUMMARY

Our Internal Medicine (IM) Medicinal Chemistry Group delivers scientific excellence in the small-molecule medicinal chemistry portfolio aligned to the IM Research Unit (IM RU). You will work within the IM Medicinal Chemistry Design Group and will contribute to the medicinal chemistry effort on projects in collaboration with the IM Research Unit and IM Medicinal Chemistry Synthesis Group. As the design chemist, you will drive a strong scientific agenda by utilizing available design tools to generate design hypotheses and contribute to target design.

You will play a key role in large, multi-disciplinary, matrix teams from project inception to delivery of clinical drug candidates. You may lead such teams, or sub-teams, within the broader matrix team structure. You will also contribute to teams of scientists looking to revolutionize our approach to the discovery and development of small-molecule and synthetically-derived drugs by combining Pfizer’s expertise and large-scale research investments with external academic and biotech collaborations.

KEY RESPONSIBILITIES

  • Apply contemporary data analysis and design tools to drive effective target design and prioritization within a project

  • Devise effective hit identification strategies to move projects through the Hit-to-Lead phase with scientific excellence, efficiency, and speed

  • Play a key role in progressing projects through the Lead Optimization phase in partnership with enabling functions within Medicine Design, including Structural Biology, Chemical Biology, Primary Pharmacology; and Pharmacokinetics and Drug Metabolism, to ensure the delivery of small-molecule/synthetic drug candidates with scientific excellence, efficiency, and speed

  • Contribute to the identification of new small-molecule projects and their entry to the portfolio through collaborations with disease area biologists

  • Play a role in enhancing the external reputation of Pfizer’s Medicinal Chemistry, Molecular Design, and synthetic Drug Discovery capabilities through publications and presentations at leading conferences

  • Work with local Medicine Design leadership to put an active program of self-development in medicinal chemistry skills in place

BASIC QUALIFICATIONS

  • Ph.D. degree in Organic/Medicinal Chemistry or related area of science with minimum 3 years related medicinal chemistry experience in the biopharmaceutical industry OR   

  • M.S. degree in Organic/Medicinal Chemistry or related area of science with minimum 7 years related medicinal chemistry experience in the biopharmaceutical industry  OR 

  • B.S. degree in Organic/Medicinal Chemistry or related area of science with minimum 9 years related medicinal chemistry experience in the biopharmaceutical industry   

  • Contemporary knowledge of the key Medicinal Chemistry concepts and design tools required for pharmaceutical drug discovery

PREFERRED QUALIFICATIONS

  • Track record of accomplishment in the biopharmaceutical industry, with examples of high impact publications from scientific work to date

  • Experience leading a medicinal chemistry team

  • Experience working in matrix teams of scientists to deliver defined objectives

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Requires occasional travel to Pfizer site in Groton, CT.


Relocation support available

Work Location Assignment: On Premise


The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.  This position requires permanent work authorization in the United States.

Research and Development



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.


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More Info

Job posting number:#7231489 (Ref:pf-4908435)
Application Deadline:Open Until Filled
Employer Location:Pfizer Inc.
New York,New York
United States
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