Staff Scientist - Immune Signaling and CAR T Cell Biology

City of Hope

Duarte, CA

Job posting number: #7235995 (Ref:10025448)

Posted: May 10, 2024

Salary / Pay Rate: $38.67 - $123.37 / hour

Application Deadline: Open Until Filled

Job Description

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The Leo Wang Lab at City of Hope is hiring a staff scientist with expertise and interest in fundamental immune signaling to join our group in the Department of Immuno-oncology. We couple protein-focused molecular techniques (mass spectrometry, capillary Western blot, flow cytometry, CyTOF) with in vitro and in vivo disease models to define the molecular basis of chimeric antigen receptor (CAR) signaling and activation. We correlate these fundamental proteomic pathways with their functional consequences and use this information to aid in the rational design of solid-tumor targeted CAR constructs with improved persistence and potency. For more information on Dr. Leo Wang’s research, please visit here.

As a successful candidate, you will:

  • Design and lead projects focused on CAR T cell signaling in multiple model systems, using canonical TCR signaling as a conceptual framework.
  • Coordinate lab tasks and operations among multiple lab members, including ordering, inventory, and other essential lab functions.
  • Keep detailed and accurate logs of experimental design and primary data, analysis, and synthesis.
  • Prepare data presentations and manuscripts for publication.
  • Initiate and maintain collaborations with other labs.
  • Travel to meetings to represent the lab and to present new data.

Your qualifications should include:

  • The Staff Scientist must possess, at a minimum, the U.S. equivalent Bachelor’s or Master’s degree in an appropriate discipline, and will often have a Ph.D. or other doctoral level degree.
  • Core competencies include cell and molecular biology, flow cytometry, protein biochemistry, and mouse work.
  • Extensive prior experience in immunology or a closely related field.

Preferred qualifications:

  • Ph.D. or equivalent degree and 5 or more years of postdoctoral experience. Programming experience (R, Python).

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here.

To learn more about our Comprehensive Benefits, pleaseCLICK HERE.

Salary / Pay Rate Information:
Pay Rate: $38.67 - $123.37 / hour

The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.



City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.


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