Research Specialist B (Biomedical Sciences)

University of Pennsylvania

Philadelphia, PA

Job posting number: #7236678

Posted: April 16, 2024

Application Deadline: Open Until Filled

Job Description

Job Description Summary

The primary purpose of this position is for an experienced individual to manage the lab’s genetically modified mouse colony and provide support for lab projects that require mouse work & functional in-vivo experimentation. This will involve the maintenance and genotyping of transgenic mice in the lab by way of tail/ear clipping, DNA extraction, and genotyping, among other skills. This will also require learning techniques such as orthotopic transplantation, tail vein injections, and else. Previous, significant, experience in mouse handling is required as is the ability to maintain an online electronic database of mice housed in the lab’s colony. In addition, the candidate is expected to perform cell culture and basic molecular biology (ex: DNA/RNA extractions, qRT-PCR, and microscopy) in support of research members of the group, including the PI, postdocs, and graduate students. Last, this position comes with flexibility in terms of intellectual engagement and further career advancement. Namely, the candidate is free to explore engagement in independent research and/or learn additional techniques employed by the lab to grow. For example, the lab has extensive experience in developing novel genomics-based approaches (e.g. sequencing, at bulk and single-cell resolution) to research problems, which the candidate may benefit from learning.
Job Description

Job Responsibilities

Manage the lab’s genetically modified/engineered mouse colony
Assist in the execution of mouse experiments such as cancer cell transplantation, therapeutic treatment, and else
Support lab projects by performing basic molecular biology and cell culture techniques
Support lab projects by closing interacting and assisting other lab members (e.g. postdocs and graduate students)
Other duties and responsibilities as assigned
Required Qualifications

Bachelor of Science and 1 to 2 years of experience or equivalent combination of education and experience is required. At least 2 years of experience preferred in handling experimental mice and animal husbandry
Experience in establishing detailed records and databases of mice in colony
Proficiency in cell culture and basic molecular biology approaches (ex: DNA/RNA purification, mini/maxi preps, cloning, etc.)
Ability to work as part of a team
Optional Qualifications (and to be learned on the job)

Expertise in biochemistry (ex: expression & purification of proteins with established protocols)
Experience in small animal surgical techniques

Apply Now

Please mention to the employer that you saw this ad on