Research Scientist – Chemical Proteomics

H. Lee Moffitt Cancer Center

Tampa, FL

Job posting number: #7242719 (Ref:hlj_53347)

Posted: May 7, 2024

Application Deadline: Open Until Filled

Job Description

Research Scientist – Chemical Proteomics


 

The Ideal Candidate:

We are seeking a highly motivated and talented Research Scientist to join our team, focusing on target identification by chemical proteomics. The Research Scientist will play a crucial role in advancing our understanding of potential cancer drug targets identified through fragment-based drug discovery screens and chemical proteomics. This position offers a unique opportunity to contribute to translational research and the development of novel therapies for cancer treatment.
 

Responsibilities:

  • Identification of Drug Targets:
    • Utilize cell biology techniques to assess the impact of different compound analogues on cancer cell behavior, proliferation or survival.
    • Design and execute click-chemistry facilitated chemical proteomics experiments to identify target proteins of compounds selected from fragment-based drug discovery screens.
    • Process samples for mass spectrometry-based proteomics analysis.
    • Visualize proteins by fluorescence imaging and Western blot analysis.
  • Experimental Design and Optimization:
    • Collaborate with medicinal chemists to design and implement linker strategies tailored to specific screening hits.
    • Develop and optimize protocols for chemical proteomics experiments in collaboration with core staff.
  • Data Analysis and Interpretation:
    • Analyze and interpret proteomics data to identify and prioritize drug targets.
    • Collaborate with bioinformaticians to integrate proteomics results with other data sets for a comprehensive analysis.
  • Collaboration and Communication:
    • Work collaboratively with multidisciplinary teams, including proteomics, medicinal chemistry, molecular biology, bioinformatics, and preclinical development.
    • The candidate will work closely within the team to facilitate downstream processing for genetic validation experiments.
    • Present findings at internal meetings, conferences, and contribute to publications.
  • Cell Line and Model Maintenance:
    • Maintain cancer cell lines for compound prioritization and chemical proteomics experiments.
  • Instrumentation and Technology:
    • Operate and maintain cutting-edge laboratory equipment and technologies related to affinity enrichment, sample processing and protein visualization.
    • Stay abreast of advancements in the field and recommend the integration of new technologies .


    • Credentials and Qualifications:

    • Minimum of three (3) years postdoctoral fellow or post PhD science experience in Chemical Biology, Biochemistry, Cancer Biology, Molecular Biology, or a related field is required.
    • Proven expertise in proteomics and affinity purification, particularly in the context of cancer biology.
    • Strong biochemistry skills, as well as mass spectrometry data analysis.
    • Excellent organizational, analytical, and communication skills.
    • Ability to work collaboratively in a team-oriented environment.

    How to Apply: Interested candidates should submit their online application, additionally include a cover letter, curriculum vitae, and contact information for three references to [email protected] and [email protected].  Please include "Research Scientist – Chemical Proteomics" in the subject line.



    Mission To create a Moffitt culture of diversity, equity, and inclusion as we strive to contribute to the prevention and cure of cancer. Vision To advance and accelerate a culture of access, equity, and inclusion. Diversity is a priority at Moffitt and is meant "to promote a culture of diversity and inclusion as we contribute to the prevention and cure of cancer." The Enterprise Equity Department focuses its efforts on eliminating those obstacles to an individual’s ability to exist within their personal comfort zone at the cancer center. Everyone is important to meeting this priority. Addressing and responding to diversity and inclusion fosters an environment where mutual respect for diverse cultures, communication styles, languages, customs, beliefs, values, traditions, experiences and other ways in which we identify ourselves, is the expectation.


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